Let's say you're lucky enough to take two weeks' vacation away from home each year. Or perhaps your job sends you on a training course for a few days. Then there's your niece's wedding, a weekend getaway or two to the country. All in all, we may spend 10 to 20 nights a year in a hotel room. That's not to be sneezed at. Or, more accurately, that's a lot to sneeze at. We'd all love to stay at five-star hotels with immaculate cleanliness, but the reality is most of us can afford only smaller, cheaper hotels—and hygiene and cleanliness may not be quite up to par. Here are 15 ideas on how to make your vacation home more pleasant, healthier and safer.