Your skin looks yellow
“Jaundice is one of the clearest signs of pancreatic cancer,” says Christopher DiMaio, MD, a gastroenterologist at The Mount Sinai Hospital in New York City. “Often, patients feel fine until one day a friend notices their eyes look yellow, then they go to the doctor and find they have advanced pancreatic cancer.” Cancers that start near the head of the pancreas can block the bile duct, preventing bile from reaching the intestines, where it helps break down fats and eventually leaves the body in the stool. This bile builds up and causes jaundice, which is yellowing of the skin or eyes. It can also cause your skin to itch, according to the American Cancer Society.